Occupational therapy practitioners work with persons with Down syndrome to help them master skills for independence through self-care like feeding and dressing, fine and gross motor skills, school performance, and play and leisure activities.

Research, education, and advocacy have led to advances in therapy, which have had a huge effect on the opportunities available to individuals with Down syndrome. The life expectancy has increased dramatically in recent decades—from 25 years old  in 1983 to 60 years old today—and people with Down syndrome are graduating high school, going to college, participating in social and recreational activities in their communities, making up a vibrant part of the workforce, living independently, and advocating for their rights.